Blood Genotype: In this article, you will learn about the different types of genotype, compatible genotype, Incompatible genotype, Remedy for incompatible genotypes as well as Cure for Sickle Cell Trait…See more details below.
Genotype is defined as the genetic constitution of an individual organism, or the two alleles inherited for a particular gene. The genotype is expressed when the information encoded in the genes’ DNA (Deoxyribonucleic Acid) is used to make protein and RNA (Ribonucleic Acid) molecules.
Genotype is different from phenotype (an individual’s physical/observable traits, such as height, eye color, and blood type). It is good to know your genotype before getting married or having babies with that handsome guy or beautiful lady whom you wish to spend the rest of your life together (relationship that will lead to conception).
The couple compatibility problem is from the sickle cell disease (a recessive disorder) a very serious medical condition with high prevalence rates in Africa south of the Sahara.
Types of Genotype ( AA, AS, AC, SS )
There are four different types of genotypes in humans; AA, AS, AC, SS. Each of these genotypes refer to the hemoglobin gene constituents on the red blood cells. AC is rare whereas AS and AC are abnormal.
AA – A homozygous dominant individual with normal phenotype and no risk of abnormal offspring.
AS – A homozygous recessive individual with an abnormal phenotype and is guaranteed to pass the abnormal gene onto offspring
AC – A person with C trait, lacks enough hemoglobin C in his red blood cells to cause anemia.
SS – An individual with Hemoglobin SS carries the most common and most severe type of sickle cell disease. This is inherited from the hemoglobin S gene mutation from both parents of an offspring.
Genotype Compatibility Chart
The table below will show you the compatible genotypes with respect to couples having in mind to bring about a relationship that will lead to conception.
Go through the Genotype Compatibility Table below and study it carefully:
|AA + AA||AA, AA, AA, AA||Excellent|
|AA + AS||AA, AS, AA, AS||Good|
|AA + SS||AS, AS, AS, AS||Fair|
|AA + AC||AA, AA, AA, AC||Good|
|AS + AS||AA, AS, AS, SS||Very Bad|
|AS + SS||AS, SS, SS, SS||Very Bad|
|AS + AC||AA, AC, AS, SS||Bad; Needs Advice|
|SS + SS||SS, SS, SS, SS||Very Bad|
|AC + SS||AS, AS, SS, SS||Very Bad|
|AC + AC||AA, AC, AC, SS||Bad; Needs Advice|
COMPATIBLE GENOTYPES FOR MARRIAGE
The gene compatibility summary goes thus;
An AA individual marries an AA. This is the best compatible genotype. With this, genotype compatibility will not be an issue to the future generation.
An AA individual marries an AS. This combination produces kids with AA and AS which is good. But sometimes if you’re not fortunate all the kids will be AS which is a limitation to their choice of partner.
An AS individual marries an AS. There is a 99% chance of having a child with SS, which brings about the sickle cell disease.
An AS and SS individual should not go into courtship that will bring about an offspring.
SS and SS individual must never go into marrying each other, because there is 100% chances of all the offspring the sickle cell disease.
Genotype Compatibility Solution – Cure for Sickle Cell Disease
The sickle cell disease has a remedy for. The only ascertain remedy that can change the genotype is the Bone Marrow Transplant (BMT).
This is the only permanent cure to SS, SC, and CC. It is a proven and only promising permanent cure.
However, it is a very expensive type of cure and can be done in a highly rated medical institution with sophisticated equipment. Although risky, but it is worth it.